A Fat Mobilizing and Anorectic Substance in the Urine of Fasting Rats.
- 1 February 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 115 (2), 424-429
- https://doi.org/10.3181/00379727-115-28931
Abstract
Summary A substance has been extracted from the urine of fasting rats that causes an increase in release of free fatty acids from rat epididymal fat pads in vitro and in the serum FFA of the rat in vivo. This fat mobilizing substance (FMS) is similar in chemical composition (containing at least 7 amino acids and some carbohydrate) and in biological activity (causing a hypoglycemia and body weight loss in addition to lipolysis) to FMS extracted from urine of fasting man by others. It does, however, cause a significant decrease of food intake in the rat, particularly in the hypothalamic hyperphagic animal.Keywords
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