PROLONGED EFFECTS OF p‐CHLOROPHENYLALANINE ON THE BLOOD PRESSURE OF CONSCIOUS NORMOTENSIVE AND DOCA/SALINE HYPERTENSIVE RATS
Open Access
- 1 January 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 56 (1), 69-75
- https://doi.org/10.1111/j.1476-5381.1976.tb06960.x
Abstract
1 In deoxycorticosterone acetate (DOCA) saline hypertensive rats a single dose of p-chlorophenylalanine methylester (PCPAME) (400 mg/kg i.p.) produced a significant fall in blood pressure (20–43 mmHg) which lasted for at least 8 days and was accompanied by a parallel depletion of brain stem 5-hydroxytryptamine (5-HT) but not of noradrenaline (NA). 2 In normotensive rats single doses of PCPAME (200 and 400 mg/kg i.p.) produced a significant hypotension (15–20 mmHg) after a latent period of 5 days. An initial pressor response (12 mmHg) was observed at the higher dose level only on day 3. 3 The hypotensive response to PCPAME (200 mg/kg i.p.) in normotensive rats was not modified by pretreatment with 5,6-dihydroxytryptamine (5,6-DHT; 50 μg i.c.v.) or 6-hydroxydopamine (6-OHDA; 3 × 250 μg intracerebroventricularly). 4 It is concluded that the hypotensive response to PCPAME in normotensive rats is independent of brain stem depletion of 5-HT and is probably not mediated by the formation of a false transmitter substance acting via central noradrenergic inhibitory pathways. The mechanism involved in the antihypertensive response to PCPAME in DOCA/saline hypertensive rats has yet to be defined.Keywords
This publication has 26 references indexed in Scilit:
- Effect of central inhibition of the 1-aminoacid decarboxylase on the hypotensive action of 5-HT precursors in catsEuropean Journal of Pharmacology, 1974
- Behavioral and biochemical effects of p-chlorophenylalanine, 3-chlorotyrosine and 3-chlorotyramine. A proposed mechanism for inhibition of self-stimulationNeuropharmacology, 1972
- Effects of 5‐Hydroxytryptophan on Arterial Blood Pressure, Body Temperature and Tissue Monoamines in the RatActa Pharmacologica et Toxicologica, 1971
- Similarities between behavioral and pharmacological actions of yohimbine and 5-hydroxytryptophan in the conscious dogEuropean Journal of Pharmacology, 1970
- EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAINJournal of Neurochemistry, 1970
- Localization of Indolealkylamines in CNSPublished by Elsevier ,1968
- An Improved Method for the Fluorimetric Determination of 5‐Hydroxytryptamine in TissuesActa Physiologica Scandinavica, 1967
- Construction and implantation of a permanent cannula for making injections into the lateral ventricle of the rat brainLife Sciences, 1966