Conjugation of Benzoic and Phenylacetic Acids During Nitrogen Storage Induced With Growth Hormone or Testosterone Propionate

Abstract

In female dogs, the relative amts. of benzoate metabolized by the 2 routes involving peptide linkage with glycine and ester linkage with glucuronic acid were not altered by growth hormone or testosterone propionate, and the latter hormone also failed to influence the course of metabolism of phenylacetate in this respect. These particular hormones were investigated because they produce N storage, which involves formation of peptide linkages. Animals receiving the same amt. of benzoate exhibit very significant individual differences with respect to the relative amts. metabolized by the 2 routes. Differences in wt. and in food intake are not the basis for this individual variation. That glycine feeding has a definite but limited effect on hippuric acid output in dogs receiving benzoate, and that conjugation with glucuronic acid becomes the more important mechanism as the amt. of ingested benzoate increases, was confirmed.