Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes
- 1 October 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 335 (6190), 519-525
- https://doi.org/10.1038/335519a0
Abstract
The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.Keywords
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