Haemodynamics and Renal Function Following Injection of Bumetanide

Abstract

Hemodynamics and renal function were investigated in 12 patients with valvular heart disease before and after injection of 2 mg bumetanide in the right heart catheter. There were no significant changes in O2 consumption, arteriovenous O2 difference, cardiac index, heart beats/min, stroke volume or right and left ventricular stroke work 35 min after the injection, whereas pulmonary and systemic arteriolar resistance showed a slight but insignificant reduction. Mean pulmonary capillary venous pressure, left ventricular end-diastolic pressure, mean pulmonary arterial pressure and mean pressure in the right atrium were highly significantly reduced after injection, systolic left ventricular pressure showing a significant but slight decrease. Creatinine and urea clearances increased considerably during the 1st 50 min after injection of bumetanide, but diminished during the 2nd period to levels somewhat lower than initial values. There was also marked increase in the clearances of Na, K, Ca, Mg and phosphate. Bumetanide appears to be a very potent diuretic which changes hemodynamic parameters towards normal values.