Microencapsulated Hepatocytes for Bioartificial Liver Support
- 1 October 1988
- journal article
- research article
- Published by Wiley in Artificial Organs
- Vol. 12 (5), 388-393
- https://doi.org/10.1111/j.1525-1594.1988.tb02793.x
Abstract
Free hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, were encapsulated within alginate-polylysine membranes and served as a liver support system. The encapsulated hepatocytes remained viable and were able to synthesize protein for up to 3 weeks in culture. Allografts of encapsulated hepatocytes replaced the function of a damaged liver and reduced the mortality rate among rats with galactosamine-induced fulminant hepatic failure.Keywords
This publication has 18 references indexed in Scilit:
- Microencapsulated Hepatocytes: an in Vitro and in Vivo StudyBiomaterials, Artificial Cells and Artificial Organs, 1987
- Replacement of Liver Function in Rats by Transplantation of Microcarrier-Attached HepatocytesScience, 1986
- Encapsulation of Rat Islets of Langerhans Prolongs Xenograft Survival in Diabetic MiceDiabetes, 1986
- Microencapsulation of living cells — A long-term delivery systemJournal of Controlled Release, 1985
- Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membraneBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984
- Comparison of Formalin- and Acetone-fixation for Immunohistochemical Detection of Carcinoembryonic Antigen (CEA) and KeratinAmerican Journal of Clinical Pathology, 1983
- Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell typeExperimental Cell Research, 1983
- Cellular Transplantation in the Treatment of Experimental Hepatic FailureScience, 1980
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLSThe Journal of cell biology, 1969
- Multiple Adenoma (Hamartoma) of the Liver Treated by Subtotal (90%) Resection:*Annals of Surgery, 1964