Normal Hemoglobin Clearances in Chronic Proteinuria.

Abstract

The ratio of simultaneously detd. renal clearance of Hb and inulin, in successive clearance periods in a group of 5 control and 3 patients with the nephrotic syndrome, indicates that the overall glomerular porosity, for Hb, of the patients with proteinuria is no greater than that of normals. All patients were tested 10 hrs. after their last meal and hydrated with 500-1000 cc. of water prior to the test. Continuous infusion was used throughout with a priming infusion of 75-100 cc. of 6% Hb soln. and 30 cc. of 10% inulin; sustaining infusion, 4 cc./min., contained 3% Hb and a proper amt. of inulin using 5% glucose.