Age-associated changes in activities of rat hepatocytes. I. Protein synthesis
- 1 December 1979
- journal article
- research article
- Published by Taylor & Francis in Experimental Aging Research
- Vol. 5 (6), 487-496
- https://doi.org/10.1080/03610737908257223
Abstract
Experiments involving simultaneous comparisons of cells from two animals establish an age-dependent decline in protein synthesis. Specific radioactivities of fractions from cells of aged animals (20 + months) are depressed 60% to 80% versus those from younger animals (2 to 14 months). Isotope ratio patterns derived by PAGE indicate that formation of a 20000 MW polypeptide of cytoribosomal origin is even more strongly and specifically depressed.This publication has 13 references indexed in Scilit:
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