Prostaglandin in renin release during sodium deprivation
- 1 December 1982
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Renal Physiology
- Vol. 243 (6), F537-F542
- https://doi.org/10.1152/ajprenal.1982.243.6.f537
Abstract
This study examined the role of prostaglandins [PG] in the macula densa-mediated increase in plasma renin activity (PRA) during dietary Na deprivation in rats. Micropuncture collections of early distal (ED) tubular fluid (TF) and measurements of PRA, arterial pressure (AP), and renal blood flow (RBF) were obtained in 4 groups of animals. Groups I and II received a normal Na diet and groups III and IV received a low Na diet; groups II and IV received indomethacin. Studies were performed after surgical denervation of the kidneys; AP and RBF were not different among the 4 groups of animals. EDTFNa delivery was lower in group III (0.20 .+-. 0.04 neq/min) and in group IV (0.16 .+-. 0.01 neq/min) animals on the low Na diet as compared with group I (0.34 .+-. 0.02 neq/min) and group II (0.32 .+-. 0.05 neq/min) animals on the normal Na diet. In association with the lower EDTFNa delivery, the animals receiving vehicle in group III had an elevated PRA (31.46 .+-. 8.81 ng/ml) as compared with group I animals on the normal Na diet receiving vehicle (4.78 .+-. 1.64 ng/ml). This rise in PRA was abolished in the animals in group IV (4.06 .+-. 0.81 ng/ml) that received indomethacin. The increase in PRA, possibly resulting from macula densa receptor stimulation, during dietary Na deprivation is dependent on PG synthesis.This publication has 19 references indexed in Scilit:
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