Modulation of the Q‐T Interval by the Autonomic Nervous System
- 1 September 1983
- journal article
- Published by Wiley in Pacing and Clinical Electrophysiology
- Vol. 6 (5), 1050-1056
- https://doi.org/10.1111/j.1540-8159.1983.tb04443.x
Abstract
Recent investigations have clarified some of the effects of the autonomic nervous system on duration and spatial distribution of the Q-T interval in humans. The use of atrial pacing to fix heart rate or 24-hour continuous electrocardiographic recording to develop a regression formula for individual patients has provided a means to interpret the effects of an intervention that alters both the heart rate and the Q-T interval. Drugs that affect the autonomic nervous system can influence Q-T interval directly or by changing rate. Bazett's formula to correct for rate may be misleading after certain drug interventions. For example, the Q-T interval during sinus rhythm or atrial pacing and the ventricular effective refractory period shorten after atropine plus propranolol, but corrected Q-T interval using Bazett's formula does not change. No change occurs in the Q-T interval during sinus rhythm or atrial pacing, or in ventricular effective refractory period after administration of propranolol although corrected Q-T interval using Bazett's formula markedly shortens. Q-T interval during sinus rhythm and atrial pacing and ventricular effective refractory period decrease after atropine but correct Q-T interval lengthens.(ABSTRACT TRUNCATED AT 250 WORDS)Keywords
This publication has 22 references indexed in Scilit:
- Influence of the autonomic nervous system on the Q-T interval in manThe American Journal of Cardiology, 1982
- Influence of heart rate and inhibition of autonomic tone on the QT interval.Circulation, 1982
- The long Q-T syndromeAmerican Heart Journal, 1975
- Sleep and Ventricular Premature BeatsCirculation, 1973
- The regulation of heart rate during sleepExperimental Brain Research, 1969
- Functional Distribution of Right and Left Stellate Innervation to the VentriclesCirculation Research, 1966
- The normal Q-T intervalAmerican Heart Journal, 1962
- Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden deathAmerican Heart Journal, 1957
- The Measurement of the Q-T Interval of the ElectrocardiogramCirculation, 1952
- Weiteres über das ElektrokardiogrammPflügers Archiv - European Journal of Physiology, 1908