The metabolism of the monochloronitrobenzenes in the rabbit
- 1 September 1956
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 64 (1), 38-44
- https://doi.org/10.1042/bj0640038
Abstract
The metabolism of o-, m- and p-chloronitrobenzene was studied in the rabbit within the limits imposed by the toxicity of these compounds. The main products excreted in urine are phenols conjugated with glucuronic and sulfuric acids. Several amino- and nitro-chlorophenols were identified by paper chromatography. 2-Amino-5-chlorophenol was isolated from urine of rabbits dosed with p-chloronltrobenzene. From all 3 isomers about 10% of the dose was excreted as free chloroaniline. Small amounts of nitrophenylmercapturic acid are formed from o- and p-chloronitrobenzene.Keywords
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