Presence of a highly repetitive and widely dispersed DNA sequence in the human genome.
- 1 March 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (3), 1508-1512
- https://doi.org/10.1073/pnas.78.3.1508
Abstract
A genomic DNA library consisting of human DNA fragments about 18 kbases long cloned in a bacteriophage .lambda. vector contained a specific repeated DNA segment. The repeated sequence is present in > 95% of the genomic library, and selected clones contain at least 2 copies of the sequence. This highly repetitive sequence (.apprxeq. 400,000 copies per haploid genome) is widely distributed in the human genome and is represented in the cytoplasmic polysomal mRNA. This sequence is homologous to the 300 base-pair Alu repeat family, the predominant repeat sequence in man.This publication has 27 references indexed in Scilit:
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