Liquid Junction and Membrane Potentials of the Squid Giant Axon
Open Access
- 1 May 1960
- journal article
- research article
- Published by Rockefeller University Press in The Journal of general physiology
- Vol. 43 (5), 971-980
- https://doi.org/10.1085/jgp.43.5.971
Abstract
The potential differences across the squid giant axon membrane, as measured with a series of microcapillary electrodes filled with concentrations of KC1 from 0.03 to 3.0 [image] or sea water, are consistent with a constant membrane potential and the liquid junction potentials calculated by the Henderson equation. The best value for the mobility of an organic univalent ion, such as isethionate, leads to a probably low, but not impossible, axoplasm specific resistance of 1.2 times sea water and to a liquid junction correction of 4 mv. for micro-electrodes filled with 3 [image] KC1. The errors caused by the assumptions of proportional mixing, unity activity coefficients, and a negligible internal fixed charge cannot be estimated but the results suggest that the cumulative effect of them may not be serious.Keywords
This publication has 17 references indexed in Scilit:
- Resting and Action Potentials of the Squid Giant Axon in Vivo The Journal of general physiology, 1960
- The mobility and diffusion coefficient of potassium in giant axons from SepiaThe Journal of Physiology, 1953
- Measurement of current‐voltage relations in the membrane of the giant axon of LoligoThe Journal of Physiology, 1952
- The normal membrane potential of frog sartorius fibersJournal of Cellular and Comparative Physiology, 1949
- The effect of sodium ions on the electrical activity of the giant axon of the squidThe Journal of Physiology, 1949
- The sodium and potassium balance in squid nerve axoplasmJournal of Cellular and Comparative Physiology, 1943
- Membrane resting and action potentials from the squid giant axonJournal of Cellular and Comparative Physiology, 1942
- Chloride in the giant axons of the squidJournal of Cellular and Comparative Physiology, 1941
- Membrane action potentials from the squid giant axonJournal of Cellular and Comparative Physiology, 1940
- Ueber die Potentialdifferenz zwischen zwei verdünnten Lösungen binärer ElectrolyteAnnalen der Physik, 1890