All clinical and laboratory means available were used to study 300 consecutive patients with suspected gastric malignancy. The cases were evaluated by means of gastric analysis (found to be 63% accurate), roentgenography (92.7% accurate), gastroscopy (95.3% accurate) and gastric cytology (97.7% accurate). The accuracy of cytological studies giving negative results was 99.3%, and that of studies giving positive results was 72.2% (of cancer patients). Exfoliative cytological study proved to be the most accurate individual test used and ranks second only to direct biopsy. However, collective evaluation of all methods of study produced a greater accuracy than did any one test. No method of treatment can, at the present time, offer much to patients who have far-advanced cancer. The over-all diagnostic approach with use of collective evaluation will result in the detection of earlier lesions for surgery and allow earlier institution of medical management for benign lesions.