[Note.—Sir Dominic John Corrigan, the author of the marvelous record of clinical observation reprinted below, was according to theLancet'snotice at the time of his death "a perfect Irishman." He practiced medicine during most of his life in Dublin, a dominant member of that brilliant group of physicians who resided there in the early part of the nineteenth century—Graves, Stokes, Robert Adams, William Wallace, who first popularized the use of iodide of potash, and Francis Rynd, the inventor of the hypodermic, being his colleagues, and John Cheyne and Colles of a slightly earlier generation. It is worth noting that he puts himself down as one of the physicians to the Charitable Infirmary, Jervis Street, Dublin. This hospital had beds for only six patients at a time, and this scanty material was probably the basis for Corrigan's observations which led to the accurate account of the pulse signs and other