Reduced Calcium Absorption after Nephrectomy in Uremic Patients
- 29 August 1974
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 291 (9), 458-460
- https://doi.org/10.1056/nejm197408292910906
Abstract
THE kidney has been implicated in calcium homeostasis by converting 25-hydroxyvitamin D3 (25-OH-D3) to 1,25-dihydroxyvitamin D3 (l,25-[OH]2 D3), the most active vitamin D metabolite in promoting calcium absorption from the gastrointestinal tract.1 Bilateral nephrectomy would prevent this biotransformation of 25-OH-D3 to l,25-(OH)2 D3, thereby possibly interfering with calcium absorption. In this study, calcium absorption decreased after nephrectomy, providing indirect support for the currently accepted role of the kidney in vitamin D metabolism.MethodsSeven patients with end-stage renal failure were studied before and after bilateral nephrectomy while awaiting renal . . .Keywords
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