THE IMMUNOLOGICALLY SPECIFIC RETENTION OF RECIRCULATING LONG-LIVED LYMPHOCYTES IN LYMPH NODES STIMULATED BY XENOGENEIC ERYTHROCYTES

Abstract

The lymph nodes of mice actively or adoptively immunized to sheep RBC and/or chicken RBC selectively retain long-lived lymphocytes after challenge with the appropriate antigen. This retention is demonstrable within 8 hr of the time of stimulation, though it probably begins even before this, and it is essentially complete within the first 24 hr. A similar selective retention is seen in nodes regional to the injection of some nonimmunogenic substances such as turpentine, but not others such as colloidal carbon or syngeneic RBC.