Asymmetric Catalytic Hydrosilylation of Ketones with Triethoxysilane Using a Chiral Binaphthol-Titanium Complex

Abstract

The asymmetric catalytic hydrosilylation of prochiral ketones with HSi(OEt)₃ using (R)-BINOL-Ti(O-i-Pr)₂ as a precatalyst is shown to proceed in excellent yields. Although the observed levels of enantioselectivity were moderate (up to 55% ee), an interesting phenomenon of ”enantioselective autoinduction” was observed.