Chronotherapy of malaria: improved efficacy of timed chloroquine treatment of patients with Plasmodium falciparum infections
- 1 July 1992
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 86 (4), 374-375
- https://doi.org/10.1016/0035-9203(92)90224-z
Abstract
The effect of routine treatment with chloroquine (10 mg/kg on days 1 and 2 and 5 mg/kg on day 3) on parasitaemia and parasitaemic profile of patients infected with Plasmodium falciparum was studied. As with P. vinckei petteri, the mid-term trophozoites of P. falciparum were the most susceptible stages to chloroquine treatment. It is suggested that, in order to diminish the frequency of drug administration and to lower the risks of chemoresistance developing, treatment should be diversified, using the drug which is most effective on the parasite stages present in the peripheral blood.Keywords
This publication has 7 references indexed in Scilit:
- Chronotherapy of malaria: An approach to malaria chemotherapyParasitology Today, 1991
- Chronotherapy of malaria: identification of drug-sensitive stage of parasite and timing of drug delivery for improved therapyAnnales de Parasitologie Humaine et Comparée, 1991
- Treatment of malaria: some considerations and limitations of the current methods of assessmentTransactions of the Royal Society of Tropical Medicine and Hygiene, 1989
- Stage Specific Actions of Antimalarial Drugs on Plasmodium falciparum in CultureThe American Journal of Tropical Medicine and Hygiene, 1989
- Response of Plasmodium Falciparum Infections to Pyrimethamine-Sulfadoxine In ThailandThe American Journal of Tropical Medicine and Hygiene, 1987
- Stage‐Dependent Effects of Chloroquine on Plasmodium falciparum In Vitro1The Journal of Protozoology, 1983
- ANTIMALARIAL ACTIVITY OF MEFLOQUINE AND QINGHAOSUThe Lancet, 1982