Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling
- 24 May 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5265), 1173-1176
- https://doi.org/10.1126/science.272.5265.1173
Abstract
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon T cell activation, the protein tyrosine phosphatase SHP-1 was found to bind to the protein tyrosine kinase ZAP-70. This interaction resulted in an increase in SHP-1 phosphatase activity and a decrease in ZAP-70 kinase activity. Expression of a dominant negative mutant of SHP-1 in T cells increased the sensitivity of the antigen receptor. Thus, SHP-1 functions as a negative regulator of the T cell antigen receptor and in setting the threshold of activation.Keywords
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