Dynorphin-A-(1-8) Is Contained Within Vasopressin Neurosecretory Vesicles in Rat Pituitary
- 9 December 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4628), 1137-1139
- https://doi.org/10.1126/science.6648526
Abstract
Dynorphin-A-(1-8), an opioid peptide widely distributed in the rat central nervous system, is present in vasopressin-containing neurosecretory cells terminating in the neural lobe of the pituitary. Electron microscopic immunocytochemistry reveals that dynorphin-A-(1-8) is contained within the same neurosecretory vesicles as vasopressin and vasopressin-associated neurophysin in the neural lobe of the rat. The results indicate that dynorphin may be released in the pituitary concomitantly with vasopressin during the antidiuretic response.This publication has 28 references indexed in Scilit:
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