Principles of ubiquitin and SUMO modifications in DNA repair
Top Cited Papers
- 25 March 2009
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 458 (7237), 461-467
- https://doi.org/10.1038/nature07963
Abstract
With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a much broader significance than had previously been assumed. Now, two decades later, ubiquitin and its cousin SUMO are implicated in a range of human diseases, including breast cancer and Fanconi anaemia, giving fresh momentum to studies focused on the relationships between ubiquitin, SUMO and DNA-repair pathways.Keywords
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