Clinical development of gene therapy for colorectal cancer
- 1 August 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 3 (8), 615-622
- https://doi.org/10.1038/nrc1147
Abstract
Colorectal cancer (CRC) is the second most common type of malignancy in Western nations. Improvements in surgical and radiotherapeutic techniques and the increased availability of new cytotoxic drugs have improved outcome, but 50% of patients still die from recurrent or metastatic disease. Several features of its natural history render CRC a good candidate for gene therapy. Techniques include gene replacement, virus-directed enzyme–prodrug therapy, immune manipulation and virotherapy, all of which have entered clinical trials.Keywords
This publication has 35 references indexed in Scilit:
- Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductaseOncogene, 2003
- Identification of FGF receptor-binding peptides for cancer gene therapyCancer Gene Therapy, 2002
- Purified herpes simplex virus thymidine kinase retroviral particles:Cancer Gene Therapy, 2002
- In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferaseGene Therapy, 2001
- Intratumoral Adenovirus-Mediated Suicide Gene Transfer for Hepatic Metastases from Colorectal Adenocarcinoma: Results of a Phase I Clinical TrialMolecular Therapy, 2001
- Can immunotherapy by gene transfer tip the balance against colorectal cancer?Gut, 1998
- Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954Gene Therapy, 1998
- In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.Journal of Clinical Investigation, 1998
- Phase I Study of Direct Administration of a Replication Deficient Adenovirus Vector Containing theE. coliCytosine Deaminase Gene to Metastatic Colon Carcinoma of the Liver in Association with the Oral Administration of the Pro-Drug 5-Fluorocytosine. The New York Hospital-Cornell Medical Center, New York, NYHuman Gene Therapy, 1997
- Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomasThe Lancet, 1992