The Effect of Hydrogen Ion Concentration and Protein Concentration on the Osmotic Pressure of Serum-proteins

Abstract

Observed osmotic pressures of serum proteins rise with increasing [rho] H. This increase is less than that calculated for ideal solutions on the basis of complete dissociation of protein and base. Presence of protein in solution reduces the activity coefficients of anions. Deviations of osmotic pressure of protein solutions from a linear relationship to protein concentrations are due to the excess of diffusible non-protein ions resulting from a Donnan equilibrium and to deviations from ideality.