Cellular and Subcellular Effects of Very Heavy Ions
- 1 January 1985
- journal article
- review article
- Published by Taylor & Francis in International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
- Vol. 48 (6), 873-892
- https://doi.org/10.1080/09553008514552041
Abstract
The biological effects of irradiation with ions of masses larger than 40 and energies up to 20 MeV per atomic mass unit are reviewed. The objects are viruses, bacterial spores, yeast and mammalian cells. Experimental parameters include loss of colony forming ability, induction of mutants, chromosomal aberrations, cell cycle progression, inhibition of biochemical activities and the formation of strand breaks. Some of the pertinent physical questions--e.g. track structure--are also discussed. It is shown that with very heavy ions the biological effectiveness is no longer unambiguously related to a single parameter like l.e.t. or Z*2/beta 2 but depends strongly on ion energy. This points to the importance of far-reaching delta-electrons. The analysis indicates also that even with very high l.e.t., cells are not killed by the passage of a single particle through their nucleus. Possible implications of the findings for fundamental radiation biology are outlined.Keywords
This publication has 72 references indexed in Scilit:
- Energy loss, range, path length, time-of-flight, straggling, multiple scattering, and nuclear interaction probabilityAtomic Data and Nuclear Data Tables, 1982
- Stopping power measurements for 3–5 MeV/nucleon 86Kr, 132Xe, 208Pb and 238U in solidsNuclear Instruments and Methods, 1980
- Irradiation chamber and sample changer for biological samplesNuclear Instruments and Methods, 1980
- Thermorestoration of Mutagenic Radiation Damage in Bacterial SporesScience, 1978
- Strong Molecular Effects in Heavy-Ion-Induced Carbon and NitrogenAuger TransitionsPhysical Review Letters, 1976
- Microdosimetric structure of heavy ion tracks in tissueRadiation and Environmental Biophysics, 1976
- Range and stopping-power tables for heavy ionsAtomic Data and Nuclear Data Tables, 1970
- Recovery of Yeast after Exposure to Densely Ionizing RadiationRadiation Research Supplement, 1967
- Mutation-Induction and Nuclear Inactivation in Neurospora crassa Using Radiations with Different Rates of Energy LossRadiation Research Supplement, 1967
- Effects of Glycerol and of Anoxia on the Radiosensitivity of Haploid Yeasts to Densely Ionizing ParticlesRadiation Research, 1963