Determination of Tricyclic Antidepressants by High-Performance Liquid Chromatography
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 5 (1), 20-23
- https://doi.org/10.1093/jat/5.1.20
Abstract
A method is described for the determination of amitriptyline, nortriptyline, imipramine and desipramine at low nanogram concentrations in serum. Separation and quantitation are performed by reversed-phase, isocratic, high-performance liquid chromatography utilizing ultraviolet detection at 210 nm. An internal standard, chloramitriptyline, is used as an aid to quantitation. Recovery of all four tricyclics is greater than 84%. The relative standard deviation for the analysis of amitriptyline, nortriptyline, imipramine and desipramine is less than 8% at a concentration of 100 ng/mL.This publication has 22 references indexed in Scilit:
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