The Inducible Quinate-Shikimate Catabolic Pathway in Neurospora crassa: Induction and Regulation of Enzyme Synthesis

Abstract

Summary: The regulation of the synthesis of the first three enzymes of the quinate-shikimate catabolic pathway in Neurospora crassa has been studied. Induction of these enzymes is promoted efficiently by quinate and less so by 5-dehydroquinate and/or 5-dehydroshikimate. Shikimate has little or no inducing ability. The kinetics and steady-state rates of synthesis of the three catabolic enzymes have been examined. It is suggested that quinate-shikimate dehydrogenase, catabolic dehydro-quinase, and 5-dehydroshikimate dehydrase are regulated coordinately.