Incidence and distribution of carcinoma in situ in testes removed for germ cell tumour: possible inadequacy of random testicular biopsy in detecting the condition
- 1 February 1990
- journal article
- research article
- Published by Wiley in Histopathology
- Vol. 16 (2), 198-200
- https://doi.org/10.1111/j.1365-2559.1990.tb01093.x
Abstract
A total of 127 testicular specimens with germ cell tumours were stained immunohistologically for placental alkaline phosphatase to investigate the presence and topographic distribution of carcinoma in situ cells adjacent to the invasive tumours. Carcinoma in situ was detected in 72% of the cases. In 60% of the cases positive in 72% of the cases. In 60% of the cases positive for placental alkaline phosphatase the distribution of carcinoma in situ was not diffuse, as claimed in the literature, but focal. Clinicians screening for carcinoma in situ by only one random biopsy have, therefore, to be aware of possible false negative results.Keywords
This publication has 6 references indexed in Scilit:
- Carcinoma in situ of the testis in infertile men. A histological, immunocytochemical, and cytophotometric study of DNA contentThe Journal of Pathology, 1989
- Placental alkaline phosphatase immunohistochemistry of intratubular malignant germ cells and associated testicular germ cell tumorsHuman Pathology, 1988
- Carcinoma‐in‐situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytomaInternational Journal of Andrology, 1987
- Bilateral testicular germ cell tumors. Report of nine cases and review of the literatureCancer, 1986
- Carcinoma in situ of testicular tissue adjacent to malignant germ-cell tumors: A study of 105 casesCancer, 1981
- Value of Testicular Biopsy in Diagnosing Carcinoma in Situ TestisScandinavian Journal of Urology and Nephrology, 1981