Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.
- 1 December 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (12), 5071-5075
- https://doi.org/10.1073/pnas.72.12.5071
Abstract
A low-molecular-weight substance found naturally in mouse serum neutralizes mouse xenotropic C-type virus. It has no effect on endogenous ecotropic viruses. This neutralizing factor does not belong to the known immunogloblin classes, and its activity is not associated with the antivirus immunoglobulins that can be detected by radioimmunoprecipitation. Preparations of xenotropic virus absorb out this neutralizing activity in mouse sera. The specificity of this factor for X-tropic virus suggests that it represents a newly recognized type of response of the host to an endogenous virus. Its possible role in the regulation of endogenous C-type viruses is considered.Keywords
This publication has 21 references indexed in Scilit:
- The H-2 Major Histocompatibility Complex and the/Immune Response Region: Genetic Variation, Function, and OrganizationAdvances in Immunology, 1975
- Host range of murine xenotropic virus: replication in avian cellsNature, 1975
- S‐tropic murine type‐C viruses: Frequency of isolation from continuous cell lines, leukemia virus preparations and normal spleensInternational Journal of Cancer, 1974
- Xenotropic Viruses: Murine Leukemia Viruses Associated with NIH Swiss, NZB, and Other Mouse StrainsScience, 1973
- AUTOGENOUS IMMUNITY TO ENDOGENOUS RNA TUMOR VIRUSThe Journal of Experimental Medicine, 1973
- Noninfectious ARK mouse embryo cell lines in which each cell has the capacity to be activated to produce infectious murine leukemia virusVirology, 1971
- Murine Leukemia Virus: High-Frequency Activation in vitro by 5-Iododeoxyuridine and 5-BromodeoxyuridineScience, 1971
- Plaque assay techniques for murine leukemia virusesVirology, 1970
- Demonstration of Biological Activity of a Murine Leukemia Virus of New Zealand Black MiceScience, 1970
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965