Acoustic Trauma in the Guinea Pig: I.Electrophysiology and Histology
- 1 January 1965
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 60 (1-6), 437-451
- https://doi.org/10.3109/00016486509127027
Abstract
Guinea pigs were exposed to a 500-cps tone at 128 dB SPL for 20 minutes. The acute animals had electrophysiological recordings by differential cochlear electrodes before and after exposure. The cochlear microphonic from Turn 3 showed (on average) a threshold shift of 51 dB and reduction of maximum voltage of 12 dB, while Turn 1 showed a shift of 20 dB and a reduction of voltage of 6 dB. Hair cell injury was proportional to the threshold shift (range 25–85 dB), but inversely related to a split sometimes seen between the Hensen's and Deiters' cells in Turn 3. Such a split apparently protected the organ of Corti. An inner ear conductive loss is postulated as the protective mechanism. In the recovery animals measurements were made 14 days after exposure and compared with normal values. Appreciable recovery occurs. Losses in Turn 1 are smaller but show less recovery.Keywords
This publication has 10 references indexed in Scilit:
- Cochlear Responses to Acoustic Transients: An Interpretation of Whole-Nerve Action PotentialsThe Journal of the Acoustical Society of America, 1962
- Shearing Motion in Scala Media of Cochlear ModelsThe Journal of the Acoustical Society of America, 1960
- Postmortem Changes in the Vestibular and Cochlear Receptors (Guinea Pig)JAMA Otolaryngology–Head & Neck Surgery, 1958
- Changes in Cochlear Endolymphatic Oxygen Availability, Action Potential, and Microphonics during and following Asphyxia, Hypoxia, and Exposure to Loud SoundsThe Journal of the Acoustical Society of America, 1958
- A laboratory method for the study of acoustic traumaThe Laryngoscope, 1958
- Recovery from acoustic trauma in the guinea pigThe Laryngoscope, 1957
- Acoustic Trauma in the Guinea PigThe Journal of the Acoustical Society of America, 1953
- Histologic changes in the organ of Corti with intense soundJournal of Comparative Neurology, 1953
- Description of Some Mechanical Properties of the Organ of CortiThe Journal of the Acoustical Society of America, 1953
- A graphic reconstruction method for the study of the organ of CortiThe Anatomical Record, 1921