Virus-Induced Alterations in Homeostasis: Alteration in Differentiated Functions of Infected Cells in Vivo
- 10 December 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 218 (4577), 1125-1127
- https://doi.org/10.1126/science.7146898
Abstract
The noncytopathic lymphocytic choriomeningitis virus displays a tropism for the anterior lobe of the murine pituitary gland. Virus replicates in cells that make growth hormone. This results in a diminished synthesis of growth hormone with a concomitant clinical picture of retarded growth and hypoglycemia. However, there is no morphologic evidence of either cell necrosis or inflammation in the anterior lobe of the pituitary. Hence, during infection in vivo, a noncytopathic virus may turn off the "differentiation" or "luxury" function of a cell while not killing that cell (loss of vital function). This is turn can disrupt homeostasis and cause disease. This model illustrates a novel way whereby viruses may cause disease.This publication has 28 references indexed in Scilit:
- Virus-induced diabetes mellitus. XX. Polyendocrinopathy and autoimmunity.The Journal of Experimental Medicine, 1981
- Induction of diabetes by cumulative environmental insults from viruses and chemicalsNature, 1980
- Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus.The Journal of Experimental Medicine, 1980
- A colloidal gold prepared with ultrasonicsCellular and Molecular Life Sciences, 1980
- Adsorption of horseradish peroxidase, ovomucoid and anti-immunoglobulin to colloidal gold for the indirect detection of concanavalin A, wheat germ agglutinin and goat anti-human immunoglobulin G on cell surfaces at the electron microscopic level: a new method, theory and application.Journal of Histochemistry & Cytochemistry, 1977
- Inhibition of immunologic injury of cultured cells infected with lymphocytic choriomeningitis virus: role of defective interfering virus in regulating viral antigenic expressionThe Journal of Experimental Medicine, 1977
- Surface markers on human B‐ and T‐lymphocytes. IX. Two‐color immunofluorescence studies on the association between EBV receptors and complement receptors on the surface of lymphoid cell linesInternational Journal of Cancer, 1976
- REGULATION OF THE PERMEABILITY TO WATER IN TOAD URINARY BLADDER: THE EFFECT OF COPPERJournal of Endocrinology, 1972
- PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTIONThe Journal of Experimental Medicine, 1969
- A NON-TRANSMISSIBLE CYTOPATHOGENIC EFFECT OF INFLUENZA VIRUS IN TISSUE CULTURE ACCOMPANIED BY FORMATION OF NON-INFECTIOUS HEMAGGLUTININSThe Journal of Experimental Medicine, 1955