Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins
- 1 September 2008
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (9), 3438-3440
- https://doi.org/10.1128/aac.00452-08
Abstract
From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.Keywords
This publication has 38 references indexed in Scilit:
- NMR Studies of a Model Antimicrobial Peptide in the Micelles of SDS, Dodecylphosphocholine, or DioctanoylphosphatidylglycerolThe Open Magnetic Resonance Journal, 2008
- Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sitesNucleic Acids Research, 2006
- Peptide Antimicrobial AgentsClinical Microbiology Reviews, 2006
- Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virusInternational Journal of Antimicrobial Agents, 2004
- The θ-Defensin, Retrocyclin, Inhibits HIV-1 EntryAIDS Research and Human Retroviruses, 2003
- Cathelicidins, multifunctional peptides of the innate immunityJournal of Leukocyte Biology, 2003
- Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid ResiduesClinical and Vaccine Immunology, 2002
- Antimicrobial peptides of multicellular organismsNature, 2002
- Evaluation of the Inactivation of Infectious Herpes Simplex Virus by Host-Defense PeptidesEuropean Journal of Clinical Microbiology & Infectious Diseases, 2000
- Helix geometry in proteinsJournal of Molecular Biology, 1988