The contribution of alterations in cardiac output to changes in arterial pressure reflexly evoked from the carotid sinus in the rabbit.
- 1 March 1977
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 265 (3), 781-793
- https://doi.org/10.1113/jphysiol.1977.sp011743
Abstract
The reflex cardiovascular effects of changes in pressure within the vascularly isolated carotid sinus were examined in 17 anesthetized rabbits. The opposite sinus was denervated and both aortic nerves were divided. Comparison of the mean values at sinus pressures of 40 and 200 mmHg showed a large reduction in systemic arterial pressure from 126 to 58 mmHg and a moderate reduction in heart rate, from 287 to 253 beats min-1. Cardiac output, measured by thermal dilution, showed only a small change, a fall from 160 to 148 ml min-1 kg-1. By contrast with this reduction in cardiac output of just over 7%, total peripheral resistance, derived by dividing mean arterial pressure by cardiac output, was halved, falling from 0.84 to 0.41 mmHg ml-1 min kg. Thus in the anesthetized rabbit changes in cardiac output make only a small contribution to the changes in systemic pressure evoked by alterations in carotid sinus pressure. Changes in total peripheral resistance are principally responsible for the effect on systemic pressure. Though the changes in output of the heart were small, there were considerable changes in the work done by the left ventricle which was approximately halved when carotid sinus pressure was raised from 40-200 mmHg.This publication has 5 references indexed in Scilit:
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