Outbreak of CTX-M-15-ProducingKlebsiella pneumoniaein the Intensive Care Unit of a French Hospital
- 1 March 2009
- journal article
- research article
- Published by Mary Ann Liebert Inc in Microbial Drug Resistance
- Vol. 15 (1), 47-54
- https://doi.org/10.1089/mdr.2009.0868
Abstract
The CTX-M-15 extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates were identified in 36 patients hospitalized from December 2006 to September 2007 in the medical intensive care unit (ICU) of the Bicêtre hospital, South Paris, France. The incidence of colonization and/or infection was 4.8%. Eighty-nine percent of the ESBL-producing K. pneumoniae isolates were acquired in the ICU, and only 8.3% of the patients were infected. Pulsed field gel electrophoresis (PFGE) analysis of the isolates showed that 32 isolates were clonally related and contained a 160-kb plasmid carrying the blaCTX-M-15, blaOXA-1, blaTEM-1, and aac6′-Ib-cr genes. CTX-M-15-producing Escherichia coli isolates collected in the ward during the same period of time contained distinct plasmids and were not clonally related. This study highlights the possible occurrence of outbreaks due to CTX-M-producing K. pneumoniae within hospital settings, whereas CTX-Ms are mostly reported in E. coli in community-acquired infections.Keywords
This publication has 40 references indexed in Scilit:
- Multiclonal Outbreak of Klebsiella pneumoniae Producing Extended-Spectrum β-Lactamase CTX-M-2 and Novel Variant CTX-M-59 in a Neonatal Intensive Care Unit in BrazilAntimicrobial Agents and Chemotherapy, 2008
- Dissemination of Clonally RelatedEscherichia coliStrains Expressing Extended-Spectrum β-Lactamase CTX-M-15Emerging Infectious Diseases, 2008
- Nationwide Study of the Prevalence, Characteristics, and Molecular Epidemiology of Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in FranceAntimicrobial Agents and Chemotherapy, 2008
- First Report of the Emergence of CTX-M-Type Extended-Spectrum β-Lactamases (ESBLs) as the Predominant ESBL Isolated in a U.S. Health Care SystemAntimicrobial Agents and Chemotherapy, 2007
- Spread of Extended-Spectrum β-Lactamase CTX-M-Producing Escherichia coli Clinical Isolates in Community and Nosocomial Environments in PortugalAntimicrobial Agents and Chemotherapy, 2007
- CTX-M β-Lactamase-Producing Escherichia coli in French Hospitals: Prevalence, Molecular Epidemiology, and Risk FactorsJournal of Clinical Microbiology, 2007
- Emergence and Outbreaks of CTX-M β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Strains in a Tunisian HospitalJournal of Clinical Microbiology, 2006
- CTX-M-Type Extended-Spectrum β-Lactamases in Italy: Molecular Epidemiology of an Emerging Countrywide ProblemAntimicrobial Agents and Chemotherapy, 2006
- Spread of Escherichia coli Strains with High-Level Cefotaxime and Ceftazidime Resistance between the Community, Long-Term Care Facilities, and Hospital InstitutionsJournal of Clinical Microbiology, 2006
- Control of a Prolonged Outbreak of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in a University HospitalClinical Infectious Diseases, 1999