Hepatic Bile Formation

Abstract

Except that hepatic excretory function is frequently disturbed during the course of many illnesses, attempts by investigators to understand the physiologic mechanisms governing bile formation might better be delayed until more fundamental knowledge has accumulated in the basic disciplines that must be applied to the problem. These disciplines include the structure of water,¹ water transport across biologic membranes,² solute transport across biologic membranes³ and the structure of membranes.⁴ In these reports studies of transport across a variety of tissues are described, but in none does one find a study of transport function of the liver. Investigators usually try to limit . . .