A clinic devoted mainly to the diagnosis and treatment of vaginal infections dealt with more than 6,000 patients (12,500 patient-visits) in a period of 13 years. An exact initial diagnosis was found necessary in choosing specific therapy, and included cultures for trichomonads, fungi, and bacteria. At subsequent visits, both clinical and microbiologic reappraisals were necessary in order to tell whether therapy needed to be prolonged or changed. The management of vaginitis in children was based on the same principles as in adults, and treatment was undertaken only after complete pelvic investigation.