Studies on the Activities of Tannins and Related Compounds; V1. Inhibitory Effects on Lipid Peroxidation in Mitochondria and Microsomes of Liver2

Abstract

The inhibitory effects of caffeoylquinic acids isloted from leaves of Artemisia species on lipid peroxidation induced by adenosine 5′-diphosphate (ADP) and ascorbic acid in rat liver mitochondria, and on that induced by ADP and nicotinamide adenine dinucleotide phosphate (NADPH) in rat liver microsomes, were determined. At the concentration of 5 × 10^-5M, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid and 3,4-di-O-caffeoylquinic acid exhibited complete inhibition of lipid peroxidation induced by the two systems decribed above. The inhibitory effects of these of these dicaffeoylquinic acids were markedly higher than those of caffeic acid, chlorogenic acid and methyl chorogenate, in both systems. The inhibitory effects of these tannins in both systems were very much stronger than that of dl-α-tocopherol.