The apolipoprotein CII gene: Subchromosomal localisation and linkage to the myotonic dystrophy locus
- 1 July 1985
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 70 (3), 271-273
- https://doi.org/10.1007/bf00273455
Abstract
The human apolipoprotein CII gene probe detects a restriction fragment length polymorphism located on chromosome 19. We have investigated the linkage of this polymorphism to the myotonic dystrophy locus in families. The two lici are closely linked with a maximum Lod score of 7.877 at 4% recombination. The close linkage and informativeness of the APOC2 polymorphism suggest that this probe may be of use for presymptomatic diagnosis of the myotonic dystrophy gene. The APOC2 gene was localised to the region 19p13–19q13 using somatic cell hybrids, providing further evidence that the myotonic dystrophy locus is situated in the central region of chromosome 19.This publication has 12 references indexed in Scilit:
- Localisation of genetic markers and orientation of the linkage group on chromosome 19Human Genetics, 1984
- The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in manHuman Genetics, 1984
- The locus for apolipoprotein E (apoE) is close to the Lutheran (Lu) blood group locus on chromosome 19Human Genetics, 1984
- Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.Proceedings of the National Academy of Sciences, 1984
- The isolation and characterization of cDNA clones for human apolipoprotein CII.Journal of Biological Chemistry, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1984
- Report of the committee on the genetic constitution of chromosomes 18, 19, 20, 21, and 22Cytogenetic and Genome Research, 1984
- Gentics and linkage relationships of the C3 polymorphism: discovery of C3‐Se linkage and assignment of LES‐C3‐DM‐Se‐PEPD‐Lu synteny to chromosome 19Clinical Genetics, 1983
- Genetic linkage between the loci for myotonic dystrophy and peptidase DAnnals of Human Genetics, 1983
- Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.1974