PURIFICATION OF AN ENDOGENOUS INHIBITOR OF SODIUM-POTASSIUM-ATPASE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 296 (5), 213-216
Abstract
Natriuretic hormone which inhibits Na+, K+-ATPase may play a role in essential hypertension. From human plasma of healthy subjects, an inhibitor of Na+, K+-ATPase was prepared, using a gel filtration followed by anion exchange chromatography and by high performance liquid chromatography on reverse phase. This low MW (< 1500 dalton) inhibitor is a substance which posesses anionic charges, and is absorbed on reverse phase. It also inhibits 3H-ouabain binding to human red blood cells.