Correlation of the effects of citric acid cycle metabolites on succinate oxidation by rat liver mitochondria and submitochondrial particles
- 1 March 1975
- journal article
- research article
- Published by Springer Nature in Journal of Bioenergetics and Biomembranes
- Vol. 7 (1), 1-15
- https://doi.org/10.1007/bf01558459
Abstract
Succinate dehydrogenase is inhibited by citrate and β-hydroxybutyrate in a complex manner, both in mitochondria and submitochondrial particles. Kinetics of inhibition in the particles points to a competitive component in the mechanism involved. Pyruvate, α-ketoglutarate, malate, and glutamate stimulate oxidation of succinate by mitochondria. Stimulation by α-ketoglutarate and glutamate is not influenced by the presence of rotenone. Stimulation by pyruvate is higher in the absence of rotenone and increases significantly in the presence of K+ and valinomycin. Pyruvate supplies in mitochondria reducing equivalents for malate dehydrogenase operating in the reverse direction-reduction of oxaloacetate to malate. Stimulation by malate is higher in the presence of rotenone.This publication has 42 references indexed in Scilit:
- Does the activation of succinate dehydrogenase affect the phosphorylating system in sub mitochondrial particles?FEBS Letters, 1973
- Oxaloacetate inhibition of succinate oxidation in tightly coupled liver mitochondria with ferricyanide as an electron acceptorBiochemical and Biophysical Research Communications, 1973
- Tightly bound oxalacetate and the activation of succinate dehydrogenaseBiochemical and Biophysical Research Communications, 1972
- Regulatory properties of succinate dehydrogenase: Activation by succinyl CoA, pH, and anionsBiochemical and Biophysical Research Communications, 1972
- On the need for regulation of succinate dehydrogenaseFEBS Letters, 1971
- Multiple control mechanisms for succinate dehydrogenase in mitochondriaBiochemical and Biophysical Research Communications, 1971
- The transport of pyruvate in rat liver mitochondriaFEBS Letters, 1971
- Oxaloacetate and adenosinetriphosphate levels during inhibition and activation of succinate oxidationBiochemical and Biophysical Research Communications, 1961
- On the relation between the activation of succinate oxidation and the activation of DPN reduction in mitochondriaBiochemical and Biophysical Research Communications, 1961
- Studies on choline dehydrogenaseBiochimica et Biophysica Acta, 1960