Spindle-Celled Tumours and Leucaemia in Mice after Injection with a Water Soluble Compound of 1:2:5:6-Dibenzanthracene

Abstract

Since the observation was first made (Burrows, Hieger and Kennaway) that spindle-celled tumours having the characters of sarcomata could be induced by the subcutaneous injection of 1:2:5:6-dibenzanthracene into rats and mice, several other compounds prepared in this Institute have been found to have similar properties. In all the experiments with these compounds three features have been constant: (1) the compounds used have been insoluble in water and have been administered either in solution in lard or olive oil, or as colloidal suspensions in water (Boyland); (2) the tumours have consisted mainly or entirely of spindle cells; (3) the primary tumours have appeared only in the immediate neighbourhood of the site of injection.