Comparison of induction of sister chromatid exchange, 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide, ifosfamide and 1-(pyridyl-3)-3, 3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice

Abstract

Data on induction of sister chromatid exchange (SCE), 8-azaguanine and ouabain-resistant mutants in V79 cells in diffusion chambers in mice treated with three chemicals were compared to determine the relationship between SCE and mutation. For 1-(pyridyl-3)-3,3-dimethyltriazene, a positive, linear correlation was demonstrated between induced SCE and mutation at both loci. For cyclophosphamide and ifosfamide, it was observed that SCE analysis was a more sensitive biological endpoint than induction of mutation.