DANLOS SYNDROME ASSOCIATED WITH CONGENITAL LIPOMATOSIS

Abstract

Margarot¹ defined the Danlos syndrome as a tetrad of symptoms consisting of: (1) hyperelasticity of the skin; (2) hyperlaxity of the joints; (3) fragility of the skin, involving especially the exposed surfaces and prominences, and (4) pseudotumors following trauma. While isolated cases exhibiting one or more of the characteristics have been described, the complete syndrome rarely occurs. No cases have been reported in the American literature. The incomplete cases consisting of cutis laxa or hyperflexibility of the joints alone may be classified as formes frustes. REPORT OF A CASE History.— M. G., a white girl, aged 9, was admitted to the pediatric division of St. Mary's Hospital for a tonsillectomy. She weighed 45½ pounds (20.6 Kg.), and the pulse rate and temperature were normal. Birth was normal. She began to talk at 1½ years and walked at 2. Dentition appeared at 7 years. The child's intelligence was normal. She