Plasmodium berghei: Detection in organs of infected mice by means of immuno-fluorescence
- 1 January 1973
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 67 (3), 410-415
- https://doi.org/10.1016/0035-9203(73)90119-3
Abstract
An immunofluorescent study of the malarial antigen in the tissues of mice infected with Plasmodium berghei (berghei strain) was conducted. In the first week of infection, the malarial antigen appears in corpuscular forms in the erythrocytes located in the vessels of the spleen, liver and kidney. From the second week onward, when antibodies to malaria begin to be detected, a new form of the malarial antigen, which appears as coarse granules, is detected in the fixed RE cells of the liver, spleen and in the glomerular endothelial and mesangial cells. There is a progressive decrease in the amount of the corpuscular form of the malarial antigen with a concomitant increase in the granular form. In the third week, most of the malarial antigen in the tissues is granular and the corpuscular form is rarely seen.Keywords
This publication has 8 references indexed in Scilit:
- Plasmodium berghei: Renal function and pathology in miceExperimental Parasitology, 1968
- Susceptibility to Plasmodium berghei: Parasitological, Biochemical and Hematological Studies in Laboratory and Wild MammalsMilitary Medicine, 1966
- Plasmodium berghei Infections in Gnotobiotic Mice and Rats: Parasitologic, Immunologic and Histopathologic ObservationsMilitary Medicine, 1966
- Freezing in an Isopentane-Liquid Nitrogen Mixture and Storage in 2-Octanol: Technical Improvements for ImmunofluorescenceStain Technology, 1966
- Detection of a Plasmodium Berghei-Antibody Complex Formed in VivoThe American Journal of Tropical Medicine and Hygiene, 1964
- Antigenic Structure of Plasmodium vinckeiScience, 1962
- Differences in the Course of Plasmodium Berghei Infections in some Hybrid and Backcross MiceThe American Journal of Tropical Medicine and Hygiene, 1956
- The Cellular Reactions to Infections with Plasmodium Berghei in the White MouseThe Journal of Infectious Diseases, 1954