Further evidence for a cAMP dependent regulation of tyrosine-3-monoxygenase induction in adrenal medulla
- 1 January 1975
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 287 (2), 213-217
- https://doi.org/10.1007/bf00510452
Abstract
Unilateral adrenal denervation caused a gradual decrease of adenylate cyclase activity in rat adrenal medulla. The extent of the increase in adrenal medullary 3′,5′-cyclic adenosine monophosphate (cAMP) content elicited by injections of carbamylcholine declined gradually following adrenal denervation. Three or nine days after denervation carbamylcholine caused rise of cAMP and a delayed increase of tyrosine-3-mono-oxygenase (TH) activity of similar magnitude in intact and denervated adrenal medullae. However, after an interval of 15 days or longer following denervation the increase in TH activity elicited by carbamylcholine was greatly reduced. These results support previous proposals that cAMP is involved as a second messenger in the trans-synaptic induction of TH.Keywords
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