Content of low density lipoprotein receptors in breast cancer tissue related to survival of patients.
- 1 March 1986
- Vol. 292 (6520), 580-582
- https://doi.org/10.1136/bmj.292.6520.580
Abstract
The content of low density lipoprotein (LDL) receptors in tissue from primary breast cancers was determined and its prognostic information compared with that of variables of established prognostic importance. Frozen tumour specimens were selected, and tissue from 72 patients (32 of whom had died) were studied. The LDL receptor content showed an inverse correlation with the survival time. Analysis by a multivariate statistical method showed that the presence of axillary metastasis, content of receptors for oestrogen and LDL, diameter of the tumour, and DNA pattern were all of prognostic value with regard to patient survival. Improved methods of predicting survival time in patients with breast cancer may be of value in the choice of treatment for individual patients.This publication has 35 references indexed in Scilit:
- LDL receptors in bovine tissues assayed as the heparin-sensitive binding of 125I-labeled LDL in homogenates: relation between liver LDL receptors and serum cholesterol in the fetus and post termBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985
- Selective uptake of a toxic lipophilic anthracycline derivative by the low density lipoprotein receptor pathway in cultured fibroblastsJournal of Medicinal Chemistry, 1985
- A simple binding assay for the determination of low-density lipoprotein receptors in cell homogenatesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985
- DNA Distribution, Cytosol Estrogen Receptors and Axillary Nodes as Prognostic Predictors in Breast CarcinomaActa Radiologica: Oncology, 1985
- In vivo assimilation of low density lipoproteins by a fibrosarcoma tumour line in miceCancer Letters, 1984
- Low-density lipoprotein metabolism in mice with soft tissue tumoursBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1984
- Retinoic acid binding proteins and steroid receptor levels in human breast cancerEuropean Journal of Cancer and Clinical Oncology, 1982
- PLASMA LIPIDS AND MORTALITY: A SOURCE OF ERRORThe Lancet, 1980
- Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cellsJournal of Supramolecular Structure, 1979
- The metabolism of low density lipoprotein in familial type II hyperlipoproteinemiaJournal of Clinical Investigation, 1972