Spontaneous hydrolysis of heroin in buffered solution
- 1 August 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 56 (4), 665-667
- https://doi.org/10.1139/y78-105
Abstract
Electron-capture gas–liquid chromatography was used to study the spontaneous hydrolysis of heroin in phosphate buffer (pH 6.4 and pH 7.4) at 23 °C. Aliquots of solution were taken over a 24-h period. After extraction at pH 8.9 into propan-2-ol (10%) – ethyl acetate, deacetylated products were made into heptafluorobutyrate derivatives which were analyzed quantitatively using nalorphine as the internal standard. Heroin decomposes to O6-monoacetylmorphine (O6-MAM) under these conditions. Further decomposition to morphine was not observed. Spontaneous hydrolysis was faster at pH 7.4 (first-order rate constant, 9.6 × 10−5 min−1) than at pH 6.4 (first-order rate constant, 3.0 × 10−5 min−1). In 24 h, the decomposition to O6-MAM was 13 and 4%, respectively.This publication has 5 references indexed in Scilit:
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