Topical Corticosteroids and Aqueous Humor Dynamics

Abstract

Locally and systemically administered corticosteroids have been implicated as a causative factor in the elevation of intraocular pressure.^1-7 Recently, the extensive studies of Armaly^8,9 and Becker¹⁰ have clearly documented the relationship of corticosteroid medication and the rise of intraocular pressure. The present investigation is a further attempt to elucidate this steroid-induced oculotensive phenomenon. Material and Methods Three groups of subjects were studied in the following manner. Group A. Open-Angle Glaucoma Patients. —The group comprised 11 patients. Eight were receiving 2% l -epinephrine hydrochloride and three were using pilocarpine. The patients were instructed to use 0.1% dexamethasone topically, one drop four times a day in one eye, while continuing their glaucoma medications in both eyes. Intraocular pressure measurements with the Goldmann Applanation Tonometer and the Mueller Electronic Tonometer were performed along with tonography at varying intervals, usually weekly. If the ocular pressure rose to 28 mm Hg by