THE EFFECTS OF 4-AMINO-N10-METHYL-PTEROYLGLUTAMIC ACID ON THE LEUKOCYTES OF THE NORMAL AND LEUKEMIC MOUSE
Open Access
- 1 February 1950
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 5 (2), 167-176
- https://doi.org/10.1182/blood.v5.2.167.167
Abstract
4-Amino-N10-methyl-pteroylglutamic acid in the usual treatment dosage caused a slight leukopenia, but no change in the differential count of normal mice. However, in animals with the Ak 4 strain of transplanted leukemia, such dosage caused prolongation of survival time, held the total leukocyte count at approximately normal levels, decreased the percentage of abnormal cells, and caused a marked delay in the appearance of leukemic infiltrations in liver, spleen, lymph nodes, kidney and bone marrow. Less than twenty hours after administration, a single massive dose of this drug caused a fall in the total leukocyte count of mice with advanced Ak 4 leukemia.Keywords
This publication has 5 references indexed in Scilit:
- BIOLOGICAL STUDIES WITH 4-AMINO-10-METHYLPTEROYLGLUTAMIC ACIDJournal of Biological Chemistry, 1949
- Studies on the chemotherapy of leukemia.II. The effect of 4-amino-pteroylglutamic acid and 4-amino-n10-methyl-pteroylglutamic acid on transplanted mouse leukemiaCancer, 1949
- Pteroylglutamic Acid Deficiency in Mice: Hematologic and Histologic Findings.Experimental Biology and Medicine, 1948
- Effect of urethane on a Transplantable Acute Lymphoid Leukemia.Experimental Biology and Medicine, 1947
- Effect of Urethane on Transplanted Leukemia of Ak Mice.Experimental Biology and Medicine, 1947