Partial N‐terminal amino acid sequence analyses and comparative tryptic peptide maps of murine Ia molecules encoded by the I‐A subregion

Abstract

The partial N-terminal amino acid sequences and tryptic peptide maps of I-A subregion products from the H-2^b, H-2^d, H-2^k and H-2^S haplotypes demonstrate that haplotype-associated differences are present in both a and β polypeptides. The genetic and evolutionary implications of these multiple amino acid substitutions and the homology relationships among Ia molecules from human, guinea pig and the I-E subregion of the mouse are discussed.